December 1, 2023

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Higher Magnesium Links With Better Bariatric Surgery Outcomes

Researchers released the review lined in this summary on researchsquare.com as a preprint that has not nonetheless been peer reviewed.

Essential Takeaways

  • In sufferers with variety 2 diabetes who underwent bariatric surgical procedures, better serum magnesium stages at baseline and 1-calendar year adhering to bariatric surgery have been affiliated with greater glycemic management and a greater likelihood of diabetic issues remission through the year immediately after bariatric operation.

Why This Issues

  • Soon after bariatric operation, micronutrient deficiencies are a person of the most prevalent and persuasive complications, and supplementation is proposed.

  • Abnormally low levels of serum magnesium are rather typical among clients with diabetes, primarily these with inadequately controlled glycemia.

  • Prior experiences have documented that small dietary magnesium intake is connected with an elevated possibility of building kind 2 diabetes and diminished glycemic manage in those people with sort 2 diabetic issues.

  • Bariatric medical procedures continues to be the most helpful remedy for serious weight problems and can guide to improvement or even resolution of variety 2 diabetic issues.

  • No regarded prior examine has assessed the relationship in between magnesium supplementation, magnesium serum levels, and glycemic command in people with style 2 diabetic issues each right before and right after bariatric surgery, nor the relationships concerning these actions and diabetic issues remission costs.

Analyze Design

  • This was a retrospective, observational examine of 403 sufferers (79% women of all ages) with weight problems (human body mass index ≥ 40 kg/m2 or ≥ 35 kg/m2 additionally comorbidities regular 45. kg/m2) and kind 2 diabetic issues who underwent bariatric operation (Roux-en-Y gastric bypass, 69% sleeve gastrectomy, 31%) and then experienced adhere to-up from January 2010 to June 2017.

  • Investigators assessed participants just just before their bariatric surgical procedure and at 1-12 months right after operation.

Crucial Final results

  • Just 4% were having magnesium supplementation at baseline, 43% experienced magnesium deficiency (serum magnesium < 1.52 mEq/L), and average serum magnesium was 1.53 mEq/L.

  • Compared with individuals with baseline magnesium ≥ 1.52 mEq/L, those with magnesium deficiency had higher A1c (7.2% vs 6.4% P < .001), higher fasting plasma glucose (FPG) (146.2 vs 117.5 mg/dL P < .001), and on average were taking more glucose-lowering drugs (1.20 vs 0.82 P = .001).

  • One-year post-surgery, among 392 evaluated participants, 78.0% were taking oral magnesium supplementation (100-450 mg/day), the prevalence of magnesium deficiency had dropped to 19%, and mean serum magnesium had risen to 1.62 mEq/L. 

  • As at baseline, those with magnesium deficiency had higher A1c (5.8% vs 5.5% P < .001), FPG (96.8 vs 89.8 mg/dL P = .003), and took more glucose-lowering drugs (1.17 vs 0.82 P = .015).

  • Insulin resistance didn’t differ by magnesium status at either timepoint.

  • One-year post-bariatric surgery, those taking magnesium supplementation compared with those not taking a supplement had lower A1c (5.5% vs 5.7% P = .007) and FPG (89.5 vs 93.3 mg/dL P = .06), with no difference in insulin sensitivity. 

  • Post-bariatric surgery, 229 patients (58%) had total remission of type 2 diabetes. Magnesium levels were higher among those with total versus no remission (1.65 vs 1.58 mEq/L P < .001).

  • One-year type 2 diabetes remission rates were 62% for those taking magnesium supplementation versus 48% of those not receiving magnesium (P = .06).

  • In multivariate analysis, baseline serum magnesium level independently predicted total remission of type 2 diabetes (odds ratio, 1.37 P < .001). Type of bariatric surgery had no significant link with remission (odds ratio, 0.90 P = .717), but both younger age and lower body mass index at baseline were also significantly linked with remission after surgery.

Limitations

  • As an observational study, the analysis was subject to potential residual confounding. It is possible that the findings depend in part on variations in diet or the intake of other important nutrients that correlate with magnesium intake.

  • The study cohort received a variety of magnesium supplements and dosages, and intake of magnesium in food was not part of the assessment.

Disclosures

This is a summary of a preprint research study, “Higher magnesium levels are associated with better glycemic control and diabetes remission postbariatric surgery,” written by researchers primarily at Centro Hospitalar Universitário de São João, Portugal on Research Square provided to you by Medscape. The study has not yet been peer-reviewed. The full text of the study can be found on researchsquare.com.